The research by Salk Institute suggested that it's not
just ‘what we eat’ but ‘when do we eat it’ that matters to our health.
In 2012, Satchidananda Panda, a Salk associate
professor, showed that mice which were fed a high-fat diet, but allowed access
to that diet for only eight hours per day, were healthier and slimmer than mice
given access to the same food for the whole day, even though the two groups
consumed the same number of calories.
The new study showed that the benefits of time
restriction was surprisingly more profound than initially thought and can
reverse obesity and diabetes in animal models.
The authors demonstrated that time restriction better
synchronizes the function of hundreds of genes and gene products in our body
with the predictable time of eating.
Amandine Chaix, a postdoctoral researcher in Panda's
lab said that the therapeutic effect of time restriction was surprising,
especially given evidence that nutritional deficiencies in early life can leave
a lasting mark on animals' metabolism.
Panda said that using this new experimental
set-up-with genetically identical mice consuming equal amounts of a given diet,
just within different time windows-gives the researchers a tool to delve
further into the causes of diabetes.
A comprehensive analysis of the blood metabolites in
time-restricted mice revealed that multiple molecular pathways that go awry in
metabolic disease are turned back to normal and protective pathways are dialed
up, Chaix further added.
Next steps include looking more in-depth at these
pathways, as well as investigating the effects of time-restricted eating in
humans.
The study is published in the journal Cell Metabolism.
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